Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer.
Angela L HughsonGary HannonNoah A SalamaTara G VroomanCaroline A StockwellBradley N MillsJesse Garrett-LarsenHaoming QiuRoula KaterjiLauren BenoodtCarl J JohnstonJoseph D MurphyEmma KrugerJian YeNicholas W GavrasDavid C KeeleyShuyang S QinMaggie L LeschJason B MuhitchTanzy M T LoveLaura M CalviEdith M LordNadia LuheshiJim ElyesDavid C LinehanScott A GerberPublished in: bioRxiv : the preprint server for biology (2023)
This study demonstrates the use of a novel combination treatment consisting of radiation and immunotherapy in murine pancreatic tumors. This treatment could effectively treat local and metastatic disease, suggesting it may have the potential to treat a cancer that has not seen a meaningful increase in survival in 5 decades.