A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone.
Anna L Ribeiro XavierBenjamin T KressSteven A GoldmanJoão R Lacerda de MenezesMaiken NedergaardPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2015)
Microglial cells are a specialized population of macrophages in the CNS, playing key roles as immune mediators. As integral components in the CNS, the microglia stand out for using the same mechanisms, phagocytosis and cytochemokine release, to promote homeostasis, synaptic pruning, and neural circuitry sculpture. Here, we addressed microglial functions in the subventricular zone (SVZ), the major postnatal neurogenic niche. Our results depict microglia as a conspicuous component of SVZ and its anterior extension, the rostral migratory stream, a pathway used by neuroblasts during their transit toward olfactory bulb layers. In addition to other unique populations residing in the SVZ niche, microglia display distinct morphofunctional properties that boost neuronal progenitor survival and migration in the mammalian brain.
Keyphrases
- inflammatory response
- neuropathic pain
- spinal cord injury
- lipopolysaccharide induced
- lps induced
- spinal cord
- cerebral ischemia
- blood brain barrier
- induced apoptosis
- palliative care
- preterm infants
- cell cycle arrest
- cell proliferation
- white matter
- oxidative stress
- brain injury
- signaling pathway
- cell death
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- free survival
- genetic diversity
- childhood cancer