Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation.

Joseph A HippensteelRyo UchimidoPatrick D TylerRyan C BurkeXiaorui HanFuming ZhangSarah A McMurtryJames F ColbertChristopher J LindsellDerek C AngusJohn A KellumDonald M YealyRobert J LinhardtNathan I ShapiroEric P Schmidt

Published in: Critical care (London, England) (2019)

Glycocalyx degradation occurs in sepsis and septic shock and is associated with in-hospital mortality. The volume of intravenous fluids administered during sepsis resuscitation is independently associated with the degree of glycocalyx degradation. These findings suggest a potential mechanism by which intravenous fluid resuscitation strategies may induce iatrogenic endothelial injury.

Keyphrases

septic shock
high dose
endothelial cells
cardiac arrest
acute kidney injury
low dose
risk assessment
cardiopulmonary resuscitation