Efficiency and Toxicity of Imatinib Mesylate combined with Atorvastatin Calcium in the Treatment of Steroid-Refractory Chronic Graft-Versus-Host Disease: A Single-center, Prospective, Single-arm, Open-label study.

Ting ChenJiaLi LiXiao WeiHan YaoLiDan ZhuJia LiuYuQing LiuPing WangYiMei FengShiChun GaoHuanFeng LiuLu WangLu ZhaoLi GaoCheng ZhangLei GaoXi ZhangPeiYan Kong

Published in: Acta haematologica (2024)

Combination treatment with imatinib mesylate and atorvastatin calcium was effective in treating SR-cGVHD and significantly decreased target organ injury, especially liver damage, indicating that T-cell regulatory function may play an important role in this process.

Keyphrases

chronic myeloid leukemia
open label
oxidative stress
clinical trial
combination therapy
transcription factor
radiation therapy
rectal cancer