Mitochondrial Ca2+ flux modulates spontaneous electrical activity in ventricular cardiomyocytes.

An XieAnyu ZhouHong LiuGuangbin ShiMan LiuKenneth R BohelerSamuel C Dudley

Published in: PloS one (2018)

Mitochondrial and sarcolemma NCX fluxes are required for ventricular automaticity. Mitochondrial Ca2+ uptake plays a modulatory role. Mitochondrial Ca2+ uptake through MCU is influenced by IP3R-dependent SR Ca2+ release.

Keyphrases

oxidative stress
heart failure
left ventricular
protein kinase
high glucose