Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness.

Dominik KoessingerDavid NovoAnna KoessingerAmerica CamposJasmine PetersLouise DuttonPeggy PaschkeDésirée ZerbstMadeleine MooreLouise MitchellMatthew NeilsonKatrina StevensonAnthony ChalmersStephen TaitJoanna BirchJames C Norman

Published in: Neuro-oncology advances (2023)

This work describes several key components of an EV-mediated mechanism though which GBM cells educate astrocytes to support infiltration of the surrounding healthy brain tissue.

Keyphrases

hyaluronic acid
induced apoptosis
cell cycle arrest
single cell
white matter
endoplasmic reticulum stress
signaling pathway
neuropathic pain
oxidative stress
resting state
spinal cord injury
pi k akt
blood brain barrier