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Histopathologic and immunophenotypic profile of a spontaneous mammary carcinoma in a male Humboldt's white-fronted capuchin (Cebus albifrons).

Thaynara Parente de CarvalhoAyisa Rodrigues de OliveiraDaniel Oliveira Dos SantosGeovanni Dantas CassaliAna Paula Vargas GarciaFernanda Mara Aragão Macedo PereiraLauro Leite Soares-NetoMonique Ferreira SilvaTatiane Alves da PaixãoRenato de Lima Santos
Published in: Journal of medical primatology (2021)
A 20-year-old male captive Humboldt's white-fronted capuchin (Cebus albifrons) that died accidentally had a small non-ulcerative mammary nodule diagnosed as a mammary carcinoma. Immunohistochemistry demonstrated that neoplastic cells were positive for pan-cytokeratin and cytokeratin-7. Approximately 20% of neoplastic cells were positive for Ki-67. Neoplastic cells expressed estrogen and progesterone receptors.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • cell death
  • signaling pathway
  • squamous cell carcinoma
  • radiation therapy
  • estrogen receptor
  • pi k akt
  • rectal cancer