Placental maternally expressed gene 3 differentially methylated region methylation profile is associated with maternal glucose concentration and newborn birthweight.
Cheng ChenYing JiangTing YanYuan ChenMengmeng YangMin LvFangfang XiJuefei LuBaihui ZhaoQiong LuoPublished in: Journal of diabetes investigation (2020)
The placental DNA methylation status in the MEG3 differentially methylated region was correlated with maternal glucose concentrations and newborn birthweight. These epigenetic adaptations might contribute to late-onset obesity, underlining the adverse intrauterine environment.
Keyphrases
- dna methylation
- late onset
- genome wide
- birth weight
- gestational age
- early onset
- gene expression
- copy number
- weight gain
- blood glucose
- pregnancy outcomes
- weight loss
- insulin resistance
- metabolic syndrome
- type diabetes
- high intensity
- high fat diet induced
- emergency department
- skeletal muscle
- resting state
- functional connectivity