Early Liver Transplantation for Severe Alcohol-Associated Hepatitis and a History of Prior Liver Decompensation.
Ethan M WeinbergMatthew DukewichNeha JakheteElizabeth StonesiferGene Y ImMichael R LuceyKirti ShettyJohn P RiceDavid W VictorMark R GhobrialAkshay ShettyStephanie M RutledgeSander S FlormanChristine HsuMohamed ShoreibahMahmoud AryanBabak J OrandiHyosun HanNorah TerraultBrian P LeePublished in: The American journal of gastroenterology (2022)
Prior liver decompensation was associated with higher risk of post-LT mortality and harmful alcohol use. These results are a preliminary safety signal and validate first decompensation as a criterion for consideration in early LT for AH patients. However, the high 3-year survival suggests a survival benefit for early LT and the need for larger studies to refine this criterion. These results suggest that prior liver decompensation is a risk factor, but not an absolute contraindication to early LT.