Childhood maltreatment and polygenic risk in bipolar disorders.

Monica AasFrank BellivierFrancesco BettellaChantal HenrySebastien GardJean-Pierre KahnTrine V LagerbergSofie R AminoffIngrid MelleMarion LeboyerStéphane JamainOle A AndreassenBruno Etain

Published in: Bipolar disorders (2019)

Our study is the first to show that less genetic risk may be needed to develop a more unstable form of BD when exposed to childhood maltreatment. Our study supports childhood trauma as an independent risk factor for BD.

Keyphrases

early life
childhood cancer
bipolar disorder
gene expression
young adults
dna methylation