EP2 and EP3 receptors as therapeutic targets for underactive bladder/detrusor underactivity due to diabetic cystopathy in a type 1 diabetic rat model.

Naritoshi SekidoTakeya OtsukiJun KidaHiroko MashimoDaisuke WakamatsuHiroki OkadaHidekazu Matsuya

Published in: Lower urinary tract symptoms (2020)

The present study was unable to demonstrate that stimulation of EP2 and EP3 receptors caused major improvements in UAB/DU due to DC. However, this equivocal result could arise from inherent limitations of the STZ-induced diabetic rat as a UAB/DU model.

Keyphrases

type diabetes
wound healing
diabetic rats
oxidative stress
spinal cord injury
dendritic cells
high glucose
botulinum toxin