Synthetic Utility of Alkyl tert -Butyl Peroxides in a Copper-Catalyzed Radical Functionalization.

Alkyl tert -butyl peroxides are prepared from the corresponding tert -alkyl precursors and tert -butyl hydroperoxide in the presence of a promoter. These substrates can be utilized in a mild copper-catalyzed radical functionalization that utilizes several coupling partners and has a broad substrate scope. A mechanistic study suggests that alkyl radical species participate in the coupling reactions.