Genetic Complexity of CC5 Staphylococcus aureus Isolates Associated with Sternal Bursitis in Chickens: Antimicrobial Resistance, Virulence, Plasmids, and Biofilm Formation.
Vanessa SilvaJessica RibeiroPedro TeixeiraPedro PintoMaria Madalena Vieira-PintoPatrícia PoetaManuela CaniçaGilberto IgrejasPublished in: Pathogens (Basel, Switzerland) (2024)
Sternal bursitis, a common inflammatory condition in poultry, poses significant challenges to both animal welfare and public health. This study aimed to investigate the prevalence, antimicrobial resistance, and genetic characteristics of Staphylococcus aureus isolates associated with sternal bursitis in chickens. Ninety-eight samples were collected from affected chickens, and 24 S. aureus isolates were identified. Antimicrobial susceptibility testing revealed resistance to multiple agents, with a notable prevalence of aminoglycoside resistance genes. Whole genome sequencing elucidated the genetic diversity and virulence profiles of the isolates, highlighting the predominance of clonal complex 5 (CC5) strains. Additionally, biofilm formation assays demonstrated moderate biofilm production capacity among the isolates. These findings underscore the importance of vigilant monitoring and targeted interventions to mitigate the impact of sternal bursitis in poultry production systems.
Keyphrases
- biofilm formation
- antimicrobial resistance
- genetic diversity
- staphylococcus aureus
- pseudomonas aeruginosa
- escherichia coli
- candida albicans
- public health
- genome wide
- cystic fibrosis
- heat stress
- methicillin resistant staphylococcus aureus
- risk factors
- gene expression
- cancer therapy
- dna methylation
- klebsiella pneumoniae
- multidrug resistant
- single cell
- transcription factor