Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum.
Duygu TosunZeynep DemirDallas P VeitchDaniel WeintraubPaul AisenClifford R JackWilliam J JagustRonald C PetersenAndrew J SaykinLeslie M ShawJohn Q TrojanowskiMichael W Weinernull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)
These findings emphasize that treatments that remove Aβ and completely stop downstream effects on tau and neurodegeneration would only be partially effective in slowing of cognitive decline or reversing cognitive impairment.