Circulating LEAP-2 is associated with puberty in girls.
Silvia Barja-FernándezJavier LugildeCecilia CastelaoRocío Vázquez-CobelaLuisa M SeoaneCarlos DiéguezRosaura LeisSulay TovarPublished in: International journal of obesity (2005) (2020)
This study reveals a sexual dimorphism in LEAP-2 levels in children and adolescents. These changes and the higher levels during puberty imply that LEAP-2 may contribute to some of the biological adaptations occurring during pubertal development in terms of food intake, energy balance, growth rate, and puberty onset. Future studies assessing LEAP-2 levels in longitudinal studies and its implications in growth rate, puberty onset, and reproductive hormones will help to understand the relevance of this hormone in this stage of life.
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