Paediatric population pharmacokinetic modelling to assess hydrocortisone replacement dosing regimens in young children.
Robin MicheletJohanna MelinZinnia P Parra-GuillenUta NeumannJ Martin WhitakerViktoria StachanowWilhelm HuisingaJohn PorterOliver BlankensteinRichard J RossCharlotte KloftPublished in: European journal of endocrinology (2020)
Current paediatric hydrocortisone treatment regimens based on either three- or four-times daily administration replicate cortisol exposure based on AUC0-24h, but the majority of cortisol levels are above or below physiological cortisol levels with low levels very common before the next dose.