Targeted gene panel analysis of Japanese patients with maturity-onset diabetes of the young-like diabetes mellitus: Roles of inactivating variants in the ABCC8 and insulin resistance genes.
Tohru YorifujiYoh WatanabeKana KitayamaYuki YamadaShinji HiguchiJun MoriMasaru KatoToru TakahashiTokuko OkudaTakane AoyamaPublished in: Journal of diabetes investigation (2022)
Causative genomic variants could be identified in at least 46.2% of clinically suspected MODY patients. ABCC8-MODY with inactivating variants could represent a distinct category of MODY. Genes of insulin resistance should be included in the sequencing panel for MODY.
Keyphrases
- copy number
- insulin resistance
- genome wide
- type diabetes
- end stage renal disease
- glycemic control
- genome wide identification
- adipose tissue
- ejection fraction
- metabolic syndrome
- high fat diet
- chronic kidney disease
- dna methylation
- polycystic ovary syndrome
- cardiovascular disease
- prognostic factors
- skeletal muscle
- single cell
- bioinformatics analysis
- pulmonary embolism
- patient reported outcomes
- drug delivery
- cancer therapy
- transcription factor
- weight loss
- patient reported