Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects.
Ayman M MousaKhaled E A SolimanFahad A AlhumaydhiAhmad Abdulaziz A AlmatroudiOsamah Al RugaieKhaled S AllemailemFaris A AlrumaihiArif KhanMohamad Y RezkMohammad Abdullah AljasirAmeen S S AlwashmiFaris F Aba AlkhaylAqel S AlbuttiHanan S SeleemPublished in: Journal of inflammation research (2021)
Based on the current results, garlic demonstrates hepatoprotective effects against trastuzumab-induced toxicity in rats. The study suggested for the first time that the coadministration of garlic with trastuzumab for treating breast or gastric cancer can augment their efficacy with minimal toxicity.