Oxymatrine screened from Sophora flavescens by cell membrane immobilized chromatography relieves histamine-independent itch.

Zhe ZhangJianhao PanTao ZhuNathalie MalewiczKaihe YeJianhui RongYong LuoYongli SituAlexei VerkhratskyYong WangJianhao ZhaoDan TangHong Nie

Published in: The Journal of pharmacy and pharmacology (2022)

This study discovered five potential anti-pruritic compounds including OMT in the SF extract, and OMT has strong anti-pruritic effects in HIS-independent itch via TRPA1 channel.

Keyphrases

mass spectrometry
oxidative stress
high speed
atopic dermatitis
ionic liquid
high resolution
capillary electrophoresis