The natural product Argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.
Paz DuranSantiago Loya-LópezDongzhi RanCheng TangAida Calderon-RiveraKimberly GomezHarrison J StrattonSun HuangYa-Ming XuE M Kithsiri WijeratneSamantha Perez-MillerZhiming ShanSong CaiAnna T GabrielsenAngie DorameKyleigh A MastersonOmar AlsbieiCynthia L MaduraGuoqin LuoAubin MoutalJohn StreicherGerald W. ZamponiA A Leslie GunatilakaRajesh KhannaPublished in: British journal of pharmacology (2022)
These results suggest that the dual effect of argentatin C on voltage-gated sodium and calcium channels supports its potential as a novel treatment for painful conditions.
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