Epidemiology, treatments, and related biomarkers of locally advanced or metastatic urothelial carcinoma in Chinese population: A scoping review.
Wang HeChanghao ChenTianxin LinQian XuChong YeJieyi DuJian HuangPublished in: Cancer medicine (2023)
Despite chemotherapy has been the main treatment choice for decades, appealing new therapeutic strategies including ICIs, targeted therapies and ADCs were applied in clinical practice. Further research on epidemiology and treatment-related biomarkers of la/mUC patients is needed given only a limited number of studies have been identified thus far. High genomic heterogeneity and complexity of molecular features were observed among la/mUC patients; thus, further studies are required to identify critical drivers and promote potential precise therapies.
Keyphrases
- end stage renal disease
- locally advanced
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- risk factors
- patient reported outcomes
- neoadjuvant chemotherapy
- gene expression
- rectal cancer
- clinical trial
- lymph node
- combination therapy
- patient reported
- risk assessment
- decision making
- copy number
- smoking cessation
- placebo controlled