Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study.

Lenine J P LiebenbergJo Ann S PassmoreFarzana OsmanJanine JewanrajAndile MtshaliJ Gerardo Garcia-LermaWalid HeneineAngela HolderDerseree ArcharySinaye NgcapuAida SivroLeila E MansoorQuarraisha Abdool KarimSalim S Abdool KarimLyle R McKinnon

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

Genital inflammation (GI) undermines topical human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) efficacy through unknown mechanisms. Here, associations between activated endocervical CD4 + T-cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI.

Keyphrases

human immunodeficiency virus
antiretroviral therapy
hiv infected
hiv positive
hepatitis c virus
men who have sex with men
hiv aids
hiv infected patients
hiv testing
oxidative stress
south africa
wound healing
reactive oxygen species
endoplasmic reticulum stress
cell cycle arrest
signaling pathway
pi k akt