Homoharringtonine combined with cladribine and aclarubicin (HCA) in acute myeloid leukemia: A new regimen of conventional drugs and its mechanism.

Fenglin Wang Min Xie Pan Chen Dan Wang Minghua Yang

Published in: Oxidative medicine and cellular longevity (2022)

HCA, as a new regimen of conventional drugs, was a safe and efficacious reinduction salvage strategy in children with refractory AML before HSCT. HCA exhibits the synergistic growth inhibition of AML cells and induces cell death mainly through apoptosis.

Keyphrases

cell cycle arrest
cell death
acute myeloid leukemia
pi k akt
induced apoptosis
endoplasmic reticulum stress
allogeneic hematopoietic stem cell transplantation
young adults
oxidative stress
cancer therapy
cell proliferation
drug induced