Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding.

Marie DeenAnders HougaardHanne Demant HansenClaus SvarerHans EibergSzabolcs LehelGitte M KnudsenMessoud Ashina

Published in: Cephalalgia : an international journal of headache (2018)

The finding of low 5-HT4 receptor binding suggests that cerebral levels of 5-HT are elevated in chronic migraine patients. This is in line with observations made in patients with episodic migraine. Elevated brain 5-HT levels may thus be an inherent trait of the migraine brain rather than a risk factor for conversion from episodic to chronic migraine.

Keyphrases

resting state
white matter
end stage renal disease
chronic kidney disease
functional connectivity
ejection fraction
newly diagnosed
peritoneal dialysis
gene expression
subarachnoid hemorrhage
patient reported outcomes
transcription factor