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Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination.

Mengmeng ZhaoZihui ZhengShanshan PengYao XuJishou ZhangJianfang LiuWei PanZheng YinShuwan XuCheng WeiMenglong WangJun WanJuan-Juan Qin
Published in: Journal of the American Heart Association (2024)
Taken together, these results indicate that EDIL3 deficiency attenuated EndMT by inhibiting USP10 dependent Smad4 deubiquitination in DCM mice.
Keyphrases
  • wound healing
  • growth factor
  • epithelial mesenchymal transition
  • signaling pathway
  • transforming growth factor
  • replacement therapy
  • small molecule
  • type diabetes
  • metabolic syndrome