[Novel tropomyosin consensus B and T epitopes involved in cross-reactivity between 10 different species. An in silico study].

Luis FangDalgys MartínezCatherine Meza-TorresAna Moreno-WooNicole Pereira-SanandrésAlex Domínguez VargasGloria GaravitoEduardo Egea

Published in: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) (2024)

These data describe three sequences that may explain the IgE cross-reactivity between the analyzed species. In addition, the consensus B and T epitopes can be used for further in vitro investigations and may help to design multiple-epitope protein-based immunotherapy for tropomyosin-related allergic diseases.

Keyphrases

genetic diversity
molecular docking
machine learning
binding protein
amino acid
small molecule
allergic rhinitis
molecular dynamics simulations