A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia.
Tommi Ala-KurikkaAlexey S PospelovMilla SummanenAleksander AlafuzoffSamu N KurkiJuha VoipioKai KailaPublished in: Epilepsia (2020)
The rate of brain pH recovery has a strong influence on post-asphyxia seizure propensity. The recurring hypoxic episodes during intermittent asphyxia promote neuronal excitability, which leads to seizures only after the suppressing effect of the hypercapnic acidosis is relieved. The present rodent model of BA is to our best knowledge the first one in which, consistent with clinical BA, behavioral and electrographic seizures are triggered after and not during the BA-mimicking insult.
Keyphrases
- temporal lobe epilepsy
- resting state
- cerebral ischemia
- white matter
- gestational age
- healthcare
- functional connectivity
- preterm infants
- signaling pathway
- high intensity
- endothelial cells
- respiratory failure
- transcranial direct current stimulation
- pregnant women
- blood brain barrier
- extracorporeal membrane oxygenation
- brain injury
- acute respiratory distress syndrome