Free p-cresyl sulfate shows the highest association with cardiovascular outcome in chronic kidney disease.
Griet GlorieuxRaymond C VanholderWim Van BiesenAnneleen PletinckEva SchepersNathalie NeirynckMarijn SpeeckaertDirk De BacquerFrancis VerbekePublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021)
Among PBUTs, free pCS shows the highest association with CV outcome in non-dialysed patients with CKD. Two markers of endothelial activation/damage that were significantly correlated with free pCS, ANGPT2 and MMP-7 were also associated with CV outcome. The hypothesis that free pCS exerts its CV toxic effects by an adverse effect on endothelial function deserves further exploration.