Genetic variation in neuropeptide Y interacts with childhood trauma to influence anxiety sensitivity.

Jacqueline Samantha WomersleyLindi MartinLize van der MerweSoraya Seedat Sian Megan Joanna Hemmings

Published in: Anxiety, stress, and coping (2021)

The NPY rs5574 A allele and rs3037354 deletion variant interact with CT to act as risk and protective factors, respectively, for AS in an ethnicity- and sex- differentiated manner. Our results reaffirm the role of NPY and gene-environment interactions in anxiety-related behaviors and reinforce the need for psychiatric genetics studies in diverse populations.

Keyphrases

sleep quality
mental health
computed tomography
copy number
genome wide
image quality
dual energy
magnetic resonance imaging
case control
binding protein
gene expression
dna methylation
physical activity
young adults
breast cancer risk