Involvement of adenosine signaling pathway in migraine pathophysiology: A systematic review of clinical studies.
Janu ThuraiaiyahLili KokotiMohammad Al-Mahdi Al-KaragholiMessoud AshinaPublished in: Cephalalgia : an international journal of headache (2022)
The present systematic review emphasizes a potentially important role of adenosine signaling in migraine pathogenesis. Further randomized and placebo-controlled clinical investigations applying adenosine receptors modulators in migraine patients are needed to further understand the adenosine involvement in migraine.
Keyphrases
- placebo controlled
- systematic review
- double blind
- protein kinase
- signaling pathway
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- phase iii
- small molecule
- open label
- phase ii
- clinical trial
- meta analyses
- peritoneal dialysis
- pi k akt
- squamous cell carcinoma
- epithelial mesenchymal transition
- study protocol
- patient reported outcomes
- oxidative stress
- radiation therapy
- patient reported