Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML.

Bin ZhangLe Xuan Truong NguyenDandan ZhaoDavid E FrankhouserHuafeng WangDinh Hoa HoangJunjing QiaoChristina AbundisMatthew BrehoveYu-Lin SuYuxin FengAnthony SteinLucy GhodaAdrianne DorranceDanilo PerrottiZhen ChenAnjia HanFlavia PichiorriJie JinTijana Jovanovic-TalismanMichael A CaligiuriCalvin J KuoAkihiko YoshimuraLing LiRussell C RockneMarcin KortylewskiYi ZhengNadia CarlessoYa-Huei KuoGuido Marcucci

Published in: Journal of hematology & oncology (2021)

Treatment-induced CD31+Sca-1high EC re-vascularization of the leukemic BM niche may represent a LSC extrinsic mechanism of treatment resistance that can be overcome with therapeutic EC miR-126 deprivation.

Keyphrases

stem cells
bone marrow
acute myeloid leukemia
long non coding rna
mesenchymal stem cells
high glucose
long noncoding rna
coronary artery disease
coronary artery bypass grafting
endothelial cells
acute lymphoblastic leukemia
percutaneous coronary intervention
stress induced