Diagnostic Utility of GATA3 and ISL1 in Differentiating Neuroblastoma From Other Pediatric Malignant Small Round Blue Cell Tumors.

Sambit Kumar MohantyPreeti DiwakerSourav K MishraShilpy JhaAnandi LoboSaroj P PandaShivani SharmaMohit KumarSamriti AroraVipra MallikDeepika JainEkta JainIndranil ChakrabartiJuhi VarshneyArshi BegMallika DixitManas R BaisakhSubhasini NaikSubrat K SahooMahmut AkgulBonnie L BalzerMahul B AminAnil V Parwani

Published in: International journal of surgical pathology (2023)

GATA3 and ISL1 may be valuable in the diagnostic work-up of neuroblastoma and may reliably be used to support the neuroblastic lineage of pediatric small round blue cell tumors. Furthermore, dual positivity helps in challenging scenarios, when there is equivocal imaging, overlapping IHC features, limited specimen, and the lack of facility for a molecular work up.

Keyphrases

single cell
transcription factor
cell therapy
high resolution
climate change
young adults
magnetic resonance
computed tomography
photodynamic therapy
long term care