Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice.

Kristina BerveBrian L WestRudolf MartiniJanos Groh

Published in: Journal of neuroinflammation (2020)

Our results demonstrate a detrimental impact of innate immune reactions in the CNS of CLN1 mice. These findings provide insights into CLN pathogenesis and may guide in the design of immunomodulatory treatment strategies.

Keyphrases

innate immune
high fat diet induced
inflammatory response
blood brain barrier
neuropathic pain
type diabetes
insulin resistance
spinal cord injury
spinal cord