DNA extracellular traps as potential biomarker of chronic haemophilic synovitis and therapeutic perspective in patients treated with PRP: A pilot study.
Paula OnetoMaria Eulalia LandroCarla DaffunchioAna Laura Douglas PriceEugenio Antonio Carrera SilvaHoracio CavigliaJulia EtulainPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2022)
The synovial and plasma levels of DNA-Elastase correlated with worse HJHS/BE suggesting that ETs formation could be a biomarker and potential therapeutic target for CHS. The intraarticular injection of PRP underlined a new potential alternative therapy, decreasing ETs formation in synovia of patients with CHS. However, our hypotheses must be confirmed in the future with better designed and more statistical power studies. Meanwhile, the use of intraarticular injections of PRP for the treatment of CHS remains controversial.