Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways.

Smita SihagSamuel C NussenzweigHenry S WalchMeier HsuKay See TanFrancisco Sanchez-VegaWalid K ChatilaSergio A De La TorreAssem PatelYelena Y JanjigianSteven MaronGeoffrey Y KuLaura H TangJaclyn HechtmanPari M ShahAbraham Jing-Ching WuDavid R JonesDaniela Molena David B SolitNikolaus SchultzMichael F Berger

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our study suggests that higher levels of genomic instability are associated with more advanced disease in esophageal adenocarcinoma. Furthermore, CDKN2A, KRAS, and SMAD4 represent prognostic biomarkers, given their strong association with poor survival.

Keyphrases

copy number
squamous cell carcinoma
epithelial mesenchymal transition
transforming growth factor
gene expression
radiation therapy
locally advanced
signaling pathway
wild type
circulating tumor cells