Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization.
Dahlia N AmatoDouglas V AmatoOlga V MavrodiWilliam B MartinSarah N SwilleyKeith H ParsonsDmitri V MavrodiDerek L PattonPublished in: ACS macro letters (2017)
We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAs derived from diallyl p -chlorobenzaldehyde acetal degrade and release p -chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAs enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.