Gasdermin D Hypermethylation Inhibits Pyroptosis And LPS-Induced IL-1β Release From NK92 Cells.

Jibran Sualeh MuhammadManju Nidagodu JayakumarNoha Mousaad ElemamThenmozhi VenkatachalamTom Kalathil RajuRifat Akram Hamoudi Azzam A Maghazachi

Published in: ImmunoTargets and therapy (2019)

Our results are the first to show that NK92 cells utilize GSDMD pathway to release IL-1β. Further, DMF and MMF which were previously shown to enhance NK cell cytotoxicity, also inhibit the inflammatory effects of these cells, making them most suitable for treating cancer patients. .

Keyphrases

nk cells
lps induced
inflammatory response
induced apoptosis
cell cycle arrest
oxidative stress
nlrp inflammasome
cell death
endoplasmic reticulum stress
signaling pathway