Folate Metabolism and Risk of Childhood Acute Lymphoblastic Leukemia: A Genetic Pathway Analysis from the Childhood Cancer and Leukemia International Consortium.
Catherine MetayerLogan G SpectorMichael E ScheurerSoyoung JeonRodney J ScottMasatoshi TakagiJacqueline ClavelAtsushi ManabeXiaomei MaElleni M HailuPhilip J LupoKevin Y UrayamaAudrey BonaventureMotohiro KatoAline MeirhaegheCharleston W K ChiangLibby M MorimotoJoseph L WiemelsPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2024)
Genetic variants in the folate pathway alone do not appear to substantially influence childhood acute lymphoblastic leukemia risk. Other mechanisms such as gene-folate interaction, DNA methylation, or maternal genetic effects may explain the observed associations with self-reported prenatal folate intake.
Keyphrases
- acute lymphoblastic leukemia
- childhood cancer
- genome wide
- dna methylation
- copy number
- young adults
- allogeneic hematopoietic stem cell transplantation
- pregnant women
- acute myeloid leukemia
- gene expression
- early life
- bone marrow
- birth weight
- body mass index
- weight gain
- preterm birth
- genome wide identification
- data analysis
- genome wide analysis