Different response to hypoxia of adipose-derived multipotent cells from obese subjects with and without metabolic syndrome.
Wilfredo Oliva-OliveraIsabel Moreno-IndiasLeticia Coín-AragüezSaid LhamyaniJuan Alcaide TorresSonia Fernández-VeledoJoan VendrellAntonio CamargoRajaa El BekayFrancisco José TinahonesPublished in: PloS one (2017)
Our results suggest that hypox-visASCs from NonMS subjects could promote healthy adipose tissue expansion, while hypox-visASCs from MS subjects appear to contribute to the decreased angiogenic potential and increased inflammation underlying adipose tissue dysfunction in obesity. Our results emphasize the importance of taking into account not only the BMI but also the metabolic profile of the subjects during the implementation of ASCs-based therapy to promote neovascularization.
Keyphrases
- adipose tissue
- metabolic syndrome
- insulin resistance
- weight loss
- high fat diet
- type diabetes
- oxidative stress
- multiple sclerosis
- healthcare
- weight gain
- endothelial cells
- uric acid
- ms ms
- high fat diet induced
- cardiovascular disease
- skeletal muscle
- bariatric surgery
- climate change
- diabetic retinopathy
- obese patients
- cell therapy
- optical coherence tomography