Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities.

Laura Sisk-HackworthJada BrownLillian SauAndrew A LevineLai Ying Ivy TamAishwarya RameshReeya S ShahEvelyn T Kelley-ThackraySophia WangAnita NguyenScott T KelleyVarykina G Thackray

Published in: Biology of sex differences (2023)

Our results indicate that sex differences in the gut microbiome are intestinal niche-specific and that sampling feces or the large intestine may miss significant sex effects in the small intestine. These results strongly support the need to consider both sex and reproductive status when studying the gut microbiome and while developing microbial-based therapies.

Keyphrases

mouse model
microbial community
gene expression
replacement therapy
genome wide