Reactive oxygen species impact on sperm DNA and its role in male infertility.
A D BuiRakesh Kumar SharmaRalf Reinhold HenkelAshok AgarwalPublished in: Andrologia (2018)
Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility. Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative stress (OS), which in turn can lead to nuclear and mitochondrial DNA damage, telomere shortening, epigenetic alterations and Y chromosomal microdeletions. In this review, we discuss how OS induces DNA damage and the types of DNA damage that can occur. We also briefly touch on the clinical consequences of OS-induced DNA damage.
Keyphrases
- dna damage
- oxidative stress
- reactive oxygen species
- diabetic rats
- dna repair
- dna methylation
- ischemia reperfusion injury
- high glucose
- polycystic ovary syndrome
- induced apoptosis
- single molecule
- copy number
- adipose tissue
- weight gain
- endothelial cells
- sensitive detection
- insulin resistance
- heat stress
- smoking cessation
- replacement therapy
- stress induced
- living cells
- circulating tumor cells