Clinical outcome following surgical resection and radiotherapy in adult patients with pleomorphic xanthoastrocytoma as defined by DNA methylation profiling.
Maximilian Y DengFelix HinzSemi HarrabiDominik SturmMartin SillAndrey KorshunovTanja EichkornJuliane Hörner-RieberKlaus HerfarthChristine JungkAndreas UnterbergStefan PfisterWolfgang WickAndreas von DeimlingDavid JonesJürgen DebusFelix SahmLaila KönigPublished in: Neuro-oncology practice (2023)
Our study demonstrated that adult patients with mcPXAs display a worse progression-free survival compared to the reported WHO grade 2 PXAs. Future matched-pair analyses are required with a non-irradiated cohort to elucidate the benefit of postoperative radiotherapy in adult patients with mcPXAs.