Next-generation diagnostics: virus capture facilitates a sensitive viral diagnosis for epizootic and zoonotic pathogens including SARS-CoV-2.
Christoph LangnerSten CalvelageKore SchlottauUte ZieglerAnne PohlmannDirk HöperMartin BeerPublished in: Microbiome (2021)
The VirBaits approach showed a high diagnostic performance, also for distantly related viruses. The bait set is modular and expandable according to the favored diagnostics, health sector, or research question. The risk of cross-contamination needs to be taken into consideration. The application of the RNA-baits principle turned out to be user friendly, and even non-experts can easily use the VirBaits workflow. The rapid extension of the established VirBaits set adapted to actual outbreak events is possible as shown for SARS-CoV-2. Video abstract.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- healthcare
- public health
- disease virus
- risk assessment
- mental health
- human health
- health information
- drinking water
- gram negative
- electronic health record
- antimicrobial resistance
- health promotion
- low cost
- loop mediated isothermal amplification
- multidrug resistant
- heavy metals
- quantum dots