Diagnostic approach with Z-score mapping to reduce artifacts caused by cerebral atrophy in regional CBF assessment of mild cognitive impairment (MCI) and Alzheimer's disease by [ 99m Tc]-ECD and SPECT.
Ikuo OdanoFumio MaeyatsuTetsuo HosoyaMami AsariKentaro ObaYasuyuki TakiPublished in: Japanese journal of radiology (2024)
The proposed approach provided more precise Z-scores with less over- or underestimation, artifacts, and improved diagnostic accuracy, being recommended for clinical studies.