Serum HMGB1 levels are independently associated with glucose clamp-derived measures of insulin resistance in women with PCOS.

Paolo MoghettiC CatellaniC SartoriM MigazziF CirilloM VillaniV BuiaB RighiM DaurizT FiersF TosiMaria Elisabeth Street

Published in: Journal of endocrinological investigation (2023)

These data suggest that HMGB1 levels are not associated with PCOS per se, but with insulin resistance. Further research should establish the underlying nature of this relationship, and whether this protein might play a role in the metabolic complications of PCOS.

Keyphrases

polycystic ovary syndrome
insulin resistance
metabolic syndrome
adipose tissue
high fat diet
type diabetes
electronic health record
skeletal muscle
risk factors
blood pressure
high fat diet induced
protein protein
blood glucose
deep learning