Parallel Kinetic Resolution of Unsymmetrical Acyclic Aliphatic syn-1,3-Diols.

Disclosed is a mild, reliable, and enantioselective catalytic parallel kinetic resolution of unsymmetrical acyclic aliphatic syn-1,3-diol derived acetals mediated by chiral phosphoric acid. This method provides stereoselective access to a variety of syn-1,3-diols as valuable building blocks with high enantioselectivity. Moreover, this mild system allows for site-selective protection of optically pure syn-1,3-diols in excellent regioselectivity.