Antibiotic prescribing for lower UTI in elderly patients in primary care and risk of bloodstream infection: A cohort study using electronic health records in England.
Laura J ShallcrossPatrick RockenschaubRuth Marion BlackburnIrwin NazarethNick FreemantleAndrew C HaywardPublished in: PLoS medicine (2020)
In this study, we observed that delaying or withholding antibiotics in older adults with suspected UTI did not increase patients' risk of BSI, in contrast with a previous study that analyzed the same dataset, but mortality was increased. Our findings highlight uncertainty around the risks of delaying or withholding antibiotic treatment, which is exacerbated by systematic differences between patients who were and were not treated immediately with antibiotics. Overall, our findings emphasize the need for improved diagnostic/risk prediction strategies to guide antibiotic prescribing for suspected UTI in older adults.
Keyphrases
- primary care
- electronic health record
- end stage renal disease
- newly diagnosed
- physical activity
- urinary tract infection
- pulmonary embolism
- ejection fraction
- chronic kidney disease
- magnetic resonance
- emergency department
- type diabetes
- adverse drug
- computed tomography
- escherichia coli
- coronary artery disease
- cardiovascular events
- peritoneal dialysis