Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study.
Rene A PosmaTrine FrøslevBente JespersenIwan C C van der HorstDaniel J TouwReimar Wernich ThomsenMaarten W N NijstenChristian Fynbo ChristiansenPublished in: Annals of intensive care (2020)
In this large observational cohort of critically ill patients, early lactate levels were strongly associated with mortality. Irrespective of the degree of hyperlactataemia, similar lactate levels were associated with a lower mortality rate in metformin users compared with metformin nonusers. Therefore, lactate levels around ICU admission should be interpreted according to metformin use.