Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia.

Maddalena Ardissino Buu Truong Eric A W SlobArt SchuermansSatoshi Yoshiji Alec P Morley Stephen Burgess Fu Siong Ng Antonio de Marvao Pradeep Natarajan Kypros H NicolaidesLiam GazianoAdam S ButterworthMichael C Honigberg

Published in: Circulation. Genomic and precision medicine (2024)

This investigation identified multiple targetable proteins linked to cardiovascular, inflammatory, and coagulation pathways, with SERPINE2, PZP, FGF5, FES, and ANP identified as pivotal proteins with likely causal roles in the development of preeclampsia. The identification of these potential targets may guide the development of targeted therapies for preeclampsia.

Keyphrases

early onset
genome wide
pregnancy outcomes
gene expression
pregnant women
dna methylation
risk assessment
climate change
drug induced