Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo.
Seyoung LeeVanessa H BraitThiruma V ArumugamMegan A EvansHyun Ah KimRobert E WiddopGrant R DrummondChristopher G SobeyEmma S JonesPublished in: Experimental & translational stroke medicine (2012)
These results indicate that CGP42112 can directly protect neurons from ischemia-like injury in vitro via activation of AT2Rs, an effect opposed by AT1R activation at high concentrations. Furthermore, systemic administration of CGP42112 can reduce functional deficits and infarct volume following cerebral ischemia in vivo.